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Dietary Interventions During Living Kidney Donations

RecruitingNAAges 18 Years - anyAllUniversity of Cologne
NCT05709600 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Monocentre, non-randomized, non-blinded, open-label interventional study to identification of relevant changes in molecular biology in proteome, phosphoproteome, lipidome, epigenome and transcriptome in pretransplant kidney biopsy samples in patients preconditioned by different dietary regimes (fasting mimicking diet vs. ketogenic diet vs. dietary restriction of sulfur containing amino acids vs. control patients)

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients \> 18 years of age * Planed living kidney transplantation (both donor and recipient are eligible) * Written informed consent Exclusion Criteria: * Vegetarian lifestyle * Body-Mass-Index (BMI) \< 18.5 kg/m2 * Calorie-reduced diet within the preceding four weeks * Underlying wasting syndrome * Contraindication for enteral nutrition * Known allergy to or intolerance of the ingredients of the diet used * Pregnancy * Breastfeeding * Absence of safe contraceptive measures or non-occurrence of menopause (in women) * Participation in other interventional trials
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What it tests

  • Fasting mimicking diet
  • Ketogenic diet
  • Dietary restriction of sulfur containing amino acids
  • Control Group ( healthy, low-fat, moderate protein and high carbohydrate diet)
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Where

1 site
Department II of Internal Medicine, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne
Cologne, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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