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Neurological Recovery Following NOS-SACD

Recruitingn/aAges 16 Years - 40 YearsAllNottingham University Hospitals NHS Trust
NCT05714917 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Nitrous oxide has become an increasingly popular recreational drug amongst young people, particularly at festivals, nightclubs and parties. Considering the drug is not illegal to possess, has low cost in the form of 'whippets' and can be easily purchased online, it has become the second most commonly used recreational drug amongst people aged 16-24 in the UK. However, nitrous oxide is known to irreversibly inactivate the functioning of vitamin B12, a vitamin required for the maintenance and proper functioning of nerves in the spinal cord. Neurological symptoms in this population have been reported in around 3.4% of nitrous oxide users, although the true incidence is expected to be higher as the cases being reported by UK hospitals continues to rise. Patients may present with adverse neurological symptoms like tingling, weakness, coordination and mobility problems. Currently, studies rev

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📋 Eligibility rules (as published)
Inclusion Criteria: * Any patient first presented with paraesthesia, weakness, ataxia or gait disturbance with a history of NOS use (age limit 16-40) as of 19/08/2024 * Patients who can read and write in English, so that they can complete the questionnaires. * Patients must have received a definitive consultant neurologist confirmed diagnosis of NOS-induced neurological damage. This is possible as all eligible patients will have been reviewed by the neurology team prior to study involvement. Exclusion Criteria: •Other causes of previous neuropathy or neurodegeneration indicated. Qualitative Interview Study: * Patients currently taking part in the longitudinal study. * Patients who report previously (clinical history) or currently (PHQ-2, clinical history) experiencing mental health difficulties.
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What it tests

  • Observational study with no interventions
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Where

3 sites
University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
Barts Health NHS Trust
London, United Kingdom
Salford Royal NHS Foundation Trust
Manchester, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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