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Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation

RecruitingNAAges 18 Years - 65 YearsAllCentral Institute of Mental Health, Mannheim
NCT05726045 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this subproject is to examine the hypothesized improvement of treatment with chess-based training and sleep enhancement, both together and on their own, in smokers. Participants will undergo fMRI measurements, sleep monitoring. They will then be assigned to one of the four experimental groups, including high-intensity interval training with or without chess-based training.

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📋 Eligibility rules (as published)
Inclusion Criteria: * severe tobacco use disorder (TUD) according to DSM-5 * sufficient ability to communicate with investigators and answer questions in both written and verbal format * ability to provide fully informed consent and to use self-rating scales * right-handedness * HIIT can be performed without the risk of side effect (medical sports check) Exclusion Criteria: * severe internal, neurological, and/or psychiatric comorbidities; other Axis I mental disorders other than TUD according to ICD-10 and DSM 5 (except for mild depression, i.e. F32.0, adjustment disorder and specific phobias) in the last 12 months * history of brain injury * severe physical diseases * common exclusion criteria for MRI (e.g. metal, claustrophobia) * positive drug screening (opioids, benzodiazepines, barbiturates, cocaine, amphetamines) * psychotropic medication within the last 14 days * pregnancy
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What it tests

  • Standard smoking cessation program (SCP)
  • Cognitive remediation treatment (CRT)
  • High-intensity interval training (HIIT evening)
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Where

1 site
Klinik für Abhängiges Verhalten, Zentralinstitut für Seelische Gesundheit
Mannheim, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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