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Fluid Challenge and Plasma Volume, During Surgery

RecruitingPhase 4Ages 18 Years - 85 YearsAllJoachim Zdolsek
NCT05726136 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml/kg body weight, albumin 5% 4 ml/kg body weight or albumin 20% 1 ml/kg body weight), using hemoglobin as a dilution indicator.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Written consent to participate in the study * For women: relevant contraceptive, menopausal or a negative pregnancy test. * ASA category I to III * Laparoscopic abdominal surgery, with a duration of at least 90 minutes. * 18 to 85 years Exclusion Criteria: * Patients with known cardiac failure * \<18 or \>85 years * known allergy to albumin * extracellular hyperhydration or hypervolemia * kidney failure * pregnancy or planned pregnancy
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What it tests

  • acetated Ringers
  • albumin 5%
  • albumin 20%
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Where

1 site
Vrinnevi Hospital
Norrköping, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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