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Efficacy of Add-on Plasma Exchange As an Adjunctive Strategy Against Septic Shock

RecruitingNAAges 18 Years - 80 YearsAllHannover Medical School
NCT05726825 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Randomized, prospective, multicenter, open-label, controlled, parallel-group interventional trial to test the adjunctive effect of therapeutic plasma exchange in patients with early septic shock.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * New onset of septic shock (\< 24 hrs), (SEPSIS-3 definition) * Norepinephrine (NE) dose โ‰ฅ 0.4 ฮผg/kg/min โ‰ฅ 30 min OR NE โ‰ฅ 0.3 ฮผg/kg/min + vasopressin (any dose) * Established vascular access suitable for plasma exchange independent of study inclusion (due to established indication of RRT, expected need for RRT within the next 48 hours or other medical reasons as assessed by treating physician team) Exclusion Criteria: * Age \< 18 or \> 80 years * Urogenital focus of infection * Pregnancy * Heparin-induced thrombocytopenia * Known reaction against fresh frozen plasma (FFP)
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What it tests

  • Therapeutic Plasma Exchange (TPE)
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Where

25 sites
University Hospital Innsbruck
Innsbruck, Austria
University Hospital Vienna
Vienna, Austria
St. Joseph Hospital
Berlin, Germany
University Hospital Berlin Charite
Berlin, Germany
University Hospital Bonn
Bonn, Germany
Hospital Braunschweig
Braunschweig, Germany
Hospital Bremerhaven
Bremerhaven, Germany
Hospital Cologne Meerheim
Cologne, Germany

โ€ฆand 17 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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