🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Cerebellar Involvement in Alcohol Use Disorder (AUD)

RecruitingNAAges 25 Years - 55 YearsAllJohns Hopkins University
NCT05732207 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The goal of this observational and interventional study is to better understand the involvement of the cerebellum in the brain reward system in persons with alcohol use disorder (AUD). The main questions it aims to answer are: 1. What is the nature of cerebellar input to the ventral tegmental area (VTA) in the brain reward system, and how is it perturbed in AUD? 2. What is the relationship between measures of cerebellar integrity and magnitude of reward activation to alcohol-related cues in cerebellar, VTA and other brain reward structures? 3. What is the therapeutic potential of cerebellar transcranial direct current stimulation (tDCS) for modulating alcohol cue reactivity, associated alcohol craving, and cerebellar - VTA functional connectivity in the brain reward system? Persons with AUD will be compared with healthy control participants.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * completed at least 8 years of education Exclusion Criteria: * Estimated Intelligence Quotient (IQ) \< 90 * less than 5th grade reading level * Left handed * Non-fluent in English * current drug use disorder other than alcohol (except nicotine and caffeine) and or recent drug use in the last 90 days * Positive breath alcohol level at time of MRI scan or discrepancies between alcohol biomarker and self-report that cannot be resolved * Exhibiting symptoms of alcohol withdrawal on visit 1 assessment * Significant current psychiatric distress and or treatment * History of any central nervous system disorder, presence of a seizure disorder, or use of anticonvulsant medication in the past 3 months * any serious medical condition detected on assessment or by medical record review; or have liver function tests more than three times normal at screening * History of metal implantation that would preclude MRI scanning; or other implants, pumps, pacemakers that would be contraindications for MRI scanning * Abnormal MRI scan or history of significant closed head trauma * Evidence of dementia * For women, pregnancy
💊

What it tests

  • cerebellar transcranial direct current stimulation
📍

Where

1 site
Johns Hopkins University School of Medicine
Baltimore, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy