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Registry Study for Optimal Management of Liver Failure in the Chinese Population

Recruitingn/aAges any - anyAllFirst Affiliated Hospital Xi'an Jiaotong Universi…
NCT05740696 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Liver failure is the most severe form of liver damage caused by viral, alcoholic, drug-related and ischemia-reperfusion factors, often combined with extrahepatic organ damage, resulting in a high mortality rate. This study intends to construct a real-world case registry database of inpatients with liver failure based on an electronic clinical data collection system through a multicenter collaborative network to study the clinical characteristics, epidemiology of bacterial and fungal infections, the impact of sarcopenia on clinical prognosis, and optimization of treatment strategies such as antiviral and artificial liver in Chinese inpatients with liver failure. The cohort and experience generated from this study will be used as a support for a series of future studies to focus on clinical issues such as infection, end-stage liver disease combined with organ failure, and early warning of

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📋 Eligibility rules (as published)
Inclusion Criteria: Patients with a diagnosis consistent with liver failure and pre-liver failure: * Extreme weakness with significant gastrointestinal symptoms such as anorexia, vomiting and abdominal distention; * Elevated alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) with progressive jaundice (TBil≥85.5 μmol/L); * Bleeding tendency with PTA ≤ 60% or INR ≥ 1.5. Exclusion Criteria: * An event or complication that, in the judgment of the investigator, significantly affects the assessment of clinical status.
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What it tests

  • ALF
  • SALF
  • ACLF
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Where

14 sites
First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
Ankang Central Hospital
Ankang, China
Xiangya Hospital of Central South University
Changsha, China
Hanzhong 3201 Hospital
Hanzhong, China
Qilu Hospital of Shandong University
Jinan, China
First Hospital of Lanzhou University
Lanzhou, China
Weinan Central Hospital
Weinan, China
Air Force Medical University Tangdu Hospital
Xi'an, China

…and 6 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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