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Emotional and Neutral Sounds for Neurophysiological Prognostic Assessment of Critically Ill Patients With a Disorder of Consciousness

Recruitingn/aAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to determine if the use of emotional sound as subject own name (SON) pronounced by a familiar voice (FV) compared to SON pronounced by a non-familiar voice (NFV) during event related potential (ERP) produced a more reliable neurophysiological P300 responses, and to assess the prognostic value of this P300 responses induced by the SON with a FV.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * patients hospitalized in ICU for cardiac arrest, stroke, subarachnoid haemorrhage or head trauma, * persistent disorder of consciousness (DoC) 12 hours after sedation weaning or patient who has benefited from a prognostic assessment for persistent DoC and who has had in this assessment an evaluation by late PEA with MMN and P300 responses only to neutral sounds ("beep" and patient's first name pronounced by an unfamiliar voice) there is more than 6 months (since April 2022) Exclusion Criteria: * Moribund patient * Uncontrolled Shock during the neurophysiological evaluation * Sedated patient * Minor patient * brain death * Known deafness * Pregnant woman * Prior inclusion in the study * Patient not affiliated to a social security system * Implementation of limitations and stop of active therapies * Patient under legal protection * Patient benefiting from State Medical Aid
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What it tests

  • Use of "expressive" sounds
  • Having benefited from a prognostic evaluation by event related potentials (without sound research methods, only neutral sounds)
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Where

2 sites
Medical ICU, HEGP Hospital, APHP.Centre
Paris, France
Medical ICU, Cochin Hospital, APHP.Centre
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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