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Chemotherapy Induced Cognitive Impairment

Recruitingn/aAges 18 Years - anyAllUniversity of Aberdeen
NCT05740787 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chemotherapy is toxic and challenges everyone differently. Most chemotherapy side-effects are known and well documented. However, the phenomenon of "chemo fog" also known as "chemobrain" has not been fully investigated and is often based on comments of breast cancer patients attending outpatient clinics during and after their chemotherapy. Changes in thinking ability like lack of concentration, loss of memory and the inability to hold a thought or even a conversation has a significant impact on the lives of breast cancer patients. Without understanding what "chemobrain" is, and what causes it, there is little that doctors can do to help at the moment. The team proposing this study believe that chemotherapy causes chemicals associated with inflammation to attack parts of the brain that are important for concentration and making new memories. Unfortunately, it is not possible to measure t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women and men \>18 years * Diagnosed with HER2 negative breast cancer * Receiving EC-Taxane or Taxane only based chemotherapy * Able to communicate in English * Willing and able to give informed consent for participation in the study. Exclusion Criteria: * Any patient whose physical condition will preclude them from lying still for the duration of the brain scan. * pre-excisting mental condition/disability * Contraindication to magnetic resonance scanning such as an implantable cardiac device.
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What it tests

  • No intervention
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Where

1 site
NHS Grampian
Aberdeen, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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