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Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

RecruitingNAAges 40 Years - anyAllStephanie Grasso
NCT05741853 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA. This stage 2 efficacy clinical trial seeks to establish the effects of culturally and linguistically tailored speech-language interventions administered to bilingual individuals with PPA. The overall aim of the intervention component of this study is to establish the relationships between the bilingual experience (e.g., how often each language is used, how "strong" each language is) and treatment response of bilinguals with PPA. Specifically, the investigators will evaluate the benefits of tailored

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📋 Eligibility rules (as published)
Inclusion Criteria: * Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011) * Bilingual in Spanish and Catalan or bilingual in Spanish and English * Different proficiency levels across languages are expected, any prior experience in both languages is acceptable * Intervention study: Score of 15 or higher on the Mini-Mental State Examination * Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination Exclusion Criteria: * Other central nervous system or medical diagnosis that can cause symptoms * Other psychiatric diagnosis that can cause symptoms * Significant, uncorrected visual or hearing impairment that would interfere with participation * Prominent initial non-speech-language impairments (cognitive, behavioral, motoric) * Intervention Study: Score of less than 15 on the Mini-Mental State Examination * Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of less than 10 on the Mini-Mental State Examination
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What it tests

  • Video-Implemented Script Training for Aphasia (VISTA)
  • Lexical Retrieval Training (LRT)
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Where

3 sites
University of Texas at Austin
Austin, United States
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital Clínic de Barcelona
Barcelona, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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