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Oral Bevacizumab-800CW and Cetuximab-800CW Administration to Detect Early Esophageal Adenocarcinomas

RecruitingPhase 2Ages 18 Years - anyAllUniversity Medical Center Groningen
NCT05745857 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Previous studies have confirmed the great potential of quantitative fluorescence molecular endoscopy (qFME) when looking at additional lesion detection initially missed by high-definition white light endoscopy (HD-WLE) for surveillance of Barrett's esophagus.

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📋 Eligibility rules (as published)
Inclusion Criteria: * BE patients without dysplasia and with suspected/diagnosed low-grade dysplasia (LGD), high-grade dysplasia (HGD) or superficial EAC and planned diagnostic and/or therapeutic endoscopy * Written informed consent is obtained Exclusion Criteria: * Patients under the age of eighteen. * Submucosal and invasive EAC, also defined as EAC with tumor, node and metastasis (TNM)-classification other than T1. * Previous radiation therapy for esophageal cancer * Known immunoglobulin allergy * Previous chemotherapy, immunotherapy or related surgery * Prior bevacizumab or cetuximab treatment * Medical or psychiatric conditions that compromise the patient's ability to give informed consent * Pregnancy or breast feeding.
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What it tests

  • Avastin
  • Erbitux
  • Fluorescence endoscopy and multi-diameter single fiber reflectance/single fiber fluorescence (MDSFR/SFF) spectroscopy
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Where

1 site
University Medical Center Groningen
Groningen, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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