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Definition of Autonomic Nervous System Involvement in Patients With Multiple Sclerosis

RecruitingNAAges 18 Years - anyAllIstituti Clinici Scientifici Maugeri SpA
NCT05748015 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this interventional non-pharmacological study is to evaluate the involvement of the autonomic nervous system in patients with relapsing-remitting and primary progressive multiple sclerosis. The main questions it aims to answer are: * Is it possible to define the characteristics of dysautonomia to improve treatment on patients with multiple sclerosis through the management of conditions such as orthostatic hypotension or thermoregulation disorders that inevitably condition the patient's life and the response to rehabilitation ? * Does the severity of the functional alterations correlate with impairment of small somatic and autonomic cutaneous nerve fibers in patients with multiple sclerosis ? * How much the involvement of the autonomic nervous system affects the clinical history and progression of the disease ? * Do different clinical variants of multiple sclerosis manifest

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📋 Eligibility rules (as published)
Inclusion Criteria: * diagnosis of relapsing-remitting and primary progressive multiple sclerosis. Exclusion Criteria: * other forms of multiple sclerosis, * known other neurological disorders * assumption of potentially neurotoxic substances or drugs.
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What it tests

  • quantification of sensory and autonomic small nerve fibers by punch skin biopsy
  • Cardiovascular Reflexes testing
  • Administration of clinical scales evaluating autonomic symptoms, pain small fiber neuropathy symptoms
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Where

2 sites
ICS Maugeri - IRCCS of Telese Terme
Telese Terme, Italy
Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II
Naples, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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