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Analgesia-First Sedation in Trauma Patients

RecruitingNAAges 18 Years - anyAllMemorialCare Health System
NCT05751863 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study's aim is to ascertain the best approach for providing sedation and pain management for patients who have sustained trauma and are requiring respiratory support from a mechanical ventilator. The common approach to patients who need mechanical ventilation is to provide continuous drips of sedatives and pain medicine and awaken the patient once a day to check the brain functions. Another approach is to provide pain medicine and reserve sedatives for only a short duration when needed. The difference between approaches has not been studied in Trauma patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. ≥ 18 years of age 2. Mechanically ventilated with an expected duration of MV ≥ 48h 3. Initiated continuous sedative/analgesic infusions by the ICU team 4. Patient is a candidate for MV weaning Exclusion Criteria: 1. Admission after resuscitation from cardiac arrest 2. Significant neurological deficit due to a chronic disorder 3. History of alcohol dependence and/or other illicit drug abuse 4. Prior administration of continuous sedative/analgesic from a transferring institution 5. Patient receiving neuromuscular blocking agents 6. Allergy to midazolam, lorazepam, and/or propofol
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What it tests

  • Analgesia First Sedation Strategy for Mechanically Ventilated (MV) Trauma Subjects
  • Protocol Directed Sedation and Daily Sedation Interruption
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Where

1 site
Long Beach Memorial Medical Center
Long Beach, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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