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Gastrointestinal Stimulation As a Treatment of Postoperative Ileus Following Extensive Surgery

RecruitingNAAges 18 Years - anyAllUniversity of Aarhus
NCT05752071 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to investigate the effect of gastrointestinal stimulation with a pacemaker on the length of postoperative bowel paralysis in patients undergoing major abdominal surgery due to metastasizing colorectal cancer, appendiceal cancer or pseudomyxoma peritonei. The main question it aims to answer is if the length of postoperative ileus is reduced when the gastrointestinal tract is stimulated with a pacemaker. All participants will undergo cytoreductive surgery +/- heated intraperitoneal chemotherapy (the standard treatment for colorectal cancer, appendiceal cancer with peritoneal carcinomatosis or pseudomyxoma peritonei). After surgery, but before the abdomen is closed a pace lead will be attached to the stomach, exteriorized trough the abdominal wall and connected to an external pacemaker. The pacemaker is either turned on (experimental group) or off (contr

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients planned for elective cytoreductive surgery with or without heated intraperitoneal chemotherapy due to either colorectal or appendiceal cancer or with peritoneal metastases or due to pseudomyxoma peritonei * Written and orally informed consent * Over 18 years of age Exclusion Criteria: * Previous upper gastric or esophageal resection * History of difficulties in swallowing or gastrointestinal stenosis * Implanted or portable electrical medical device e.g. cardiac pacemaker, defibrillator or infusion pump etc. * Pregnant or breast-feeding women
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What it tests

  • Gastric electrical stimulation
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Where

1 site
Aarhus University Hospital
Aarhus, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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