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Feasibility of Transcranial Focused Ultrasound to Measure Brain Tumor

RecruitingNAAges 18 Years - anyAllUniversity of Minnesota
NCT05755399 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Transcranial focused ultrasound (tFUS) offers a platform for non-invasive imaging and treatment of the brain and pathology of the brain -- allowing high resolution imaging in both spatial and temporal dimensions. Compared with the gold- standard for brain imaging, magnetic resonance imaging (MRI), ultrasound offers reduced contrast while providing improved sampling in time through a significantly more cost-effective approach. In addition, while MRI is used to guide invasive treatments, only ultrasound can offer treatments through three primary mechanisms: 1) neuromodulation, 2) blood brain barrier modulation, and thermal/mechanical ablation through high intensity focused ultrasound (HIFU). All three treatment options require targeting therapy through the skull, which remains a barrier to clinical translation. This proposal is to test the feasibility of acquiring noninvasive targeting ima

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📋 Eligibility rules (as published)
Inclusion Criteria: * Able to undergo informed consent * Scheduled and present for brain surgery * General Anesthesia planned * Neuronavigation used for surgery * Thin cut post-contrast imaging available for coregistration * At least 18 years of age Exclusion Criteria: * Awake craniotomy planned * Unhealed wounds or infection of scalp * Diseases and conditions that would increase the morbidity and mortality of craniotomy and tumor resection (e.g. cardiopulmonary issues) in the opinion of the PI. * Pregnancy (also generally required for surgery)
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What it tests

  • Brain imaging using transcranial focused ultrasound (tFUS)
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Where

1 site
University of Minnesota
Minneapolis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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