Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF

Inclusion Criteria: * Patient admitted to the hospital with a primary diagnosis of ADHF * Patient has signs of volume overload as evidence by a score of ≥ 4 on the EVEREST score * Patient with Left Ventricular Ejection Fraction LVEF \>15% * Patient has compromised response to diuretics * NT-proBNP \>450 pg/mL if aged \<55 years, \>900 pg/mL if aged between 55 and 75 years and \>1800 pg/mL if aged \>75 years Exclusion Criteria: * Patient with active DVT or history of DVT * Patient has documented or evidence of Renal artery stenosis * BMI\>35 Kg/m\^2 * Patient has documented, untreated symptomatic coronary artery disease (CAD) requiring revascularization * Patient is in Cardiogenic shock * Patient has blood dyscrasia, acute anemia, thrombocytopenia, bleeding diathesis, or coagulopathy * Temperature \> 38°C, or sepsis, or active systemic infection requiring IV anti-microbial treatment * Patient has shown liver cirrhosis or has signs of liver damage