🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults

RecruitingEARLY Phase 1Ages 45 Years - 85 YearsAllUniversity of Florida
NCT05761860 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Individuals fluent in English will participate. * Must report some experience with opioids (e.g., oxycodone, defined as use at least once in the subject's lifetime). * Be within 20% of their ideal body weight. * Are not currently experiencing chronic pain (pain on most days during the past 3 months) * Have a systolic blood pressure of \<=140 and diastolic blood pressure of \<= 90, and a heart rate \<= 90 beats per minute. * Participants must also have a normal electrocardiogram (EKG) reading and bloodwork indicating no major health contraindications. Exclusion Criteria: * Significant current physical disease or major (uncontrolled) psychiatric disorder. * No self-reported current interest in drug abuse treatment. * Women who are pregnant or nursing. * Any severe comorbid illicit substance use disorders or current clinically significant withdrawal for any abused drug excluding nicotine and caffeine.
💊

What it tests

  • OxyCODONE 5 mg Oral Tablet
  • OxyCODONE 2.5 mg Oral Tablet
  • Placebo oxyCODONE Oral Tablet
  • Oxytocin Nasal Spray (48 IU)
  • Placebo Oxytocin Nasal Spray
📍

Where

1 site
University of Florida
Gainesville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy