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CT Evaluation of Carotid Plaque Components

Recruitingn/aAges 18 Years - anyAllUniversity of Pennsylvania
NCT05764772 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to validate the diagnostic performance of photon counting/spectral CT to distinguish tissue components in ischemic stroke with MRI, semi-automated segmentation software or histology as the reference standard. The main question\[s\] it aims to answer are: 1. Presence or absence of calcium, hemorrhage, and lipid plaque components as determined on CT will be confirmed with carotid MRI, segmentation quantitative (e.g., volume) output from segmentation software, or histologic staining. 2. Volumes of hemorrhage, lipid, and calcium components will be measured to determine plaque phenotype and correlated with ipsilateral intracranial stroke burden. Participants will be asked to do the following: Aim 1: * 1 Photon counting/spectral CT angiography of the neck * 1 Research Carotid/Neck MRI of the carotid arteries (if eligible) Aim 2: * 1 Research Carot

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with symptomatic carotid stenosis with ipsilateral ischemic infarcts attributable to the carotid disease * At least 1mm of noncalcified plaque on same side of stroke * Brain MRI documenting ischemic infarct in distribution attributable to ipsilateral carotid disease * Patients planned to undergo carotid endarterectomies * Patients must be able to read and understand English * Participants must sign the informed consent form Exclusion Criteria: * Exclusion Criteria * Patients less than 18 years old * Women who are pregnant and/or nursing
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What it tests

  • Not listed
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Where

1 site
University of Pennsylvania Hospital
Philadelphia, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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