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Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation

RecruitingNAAges 18 Years - 85 YearsAllIstituto Auxologico Italiano
NCT05766059 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Paired associative stimulation (PAS) is a non-invasive brain stimulation protocol, where two stimuli (a peripheral and a cortical one, the latter delivered with transcranial magnetic stimulation - TMS) are repeatedly associated to enhance plasticity in the brain. In the present study, a new cross-modal, visuo-motor PAS protocol - called "mirror-PAS"- will be tested as a possible non-invasive brain stimulation treatment in neurological rehabilitation to promote motor recovery and pain reduction. Participants will perform the standard PAS targeting the motor system and the recently developed mirror-PAS in two separate sessions. The investigators will compare the possible effect of the protocols in terms of neurophysiological and behavioral outcomes to identify the optimal PAS method to enhance plasticity and promote sensory-motor function.

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📋 Eligibility rules (as published)
Inclusion criteria for stroke patients: * age from 18 to 85 years * single, unilateral, hemispheric stroke (cortical or sub-cortical areas) * stroke confirmed by neuroimaging (CT or MRI) * stroke at least 4 months before enrollment * hemiparesis of the upper limb resulting from stroke or hemianesthesia clinically documented Exclusion criteria for stroke patients: * contraindications to TMS (Rossi et all, 2021) * other neurological conditions (e.g., Parkinson's Disease, Multiple Sclerosis, ALS) * other orthopedic condition that affected the hand (e.g., carpal tunnel syndrome) Inclusion criteria for PLP patients: * age from 18 to 90 years * amputation of one part of the upper limb at least 2 months before enrollment * presence of stable phantom limb pain at least 2 months prior to enrollment Exclusion criteria for PLP patients: * contraindications to TMS (Rossi et all, 2021) * other neurological, orthopedical or psychiatric conditions
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What it tests

  • Transcranial Magnetic Stimulation
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Where

1 site
Istituto Auxologico Italiano IRCCS
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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