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Provider-Mediated Communication of Genetic Testing Results to At-Risk Relatives of Cancer Patients to Improve Genetic Counseling and Testing Rates, Family HOPE Study

RecruitingNAAges 18 Years - anyAllCity of Hope Medical Center
NCT05772130 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This clinical trial tests whether provider-mediated communication of genetic testing results to at-risk relatives of cancer patients can help improve genetic counseling and testing rates. Approximately 15% of people with cancer have an inherited form of cancer due to changes in a gene that they have inherited from one of their parents. These changes increase a person's risk for developing cancer. Most people who have an inherited harmful change in a cancer risk gene don't know that they have it and are therefore not able to get the health care that they need. The primary reason for this problem has been a lack of genetic counseling and testing for cancer patients and patients with a strong family history of cancer. Another reason for this lack of awareness is that, when cancer runs in a family, the patient who carries the gene change usually has to communicate the genetic risk informatio

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📋 Eligibility rules (as published)
Inclusion Criteria: * PATIENTS: Enrolled in City of Hope (COH) institutional review board (IRB) 07047 or have been seen by COH Genetics for genetic testing * PATIENTS: Have an pathogenic/ likely pathogenic germline variant * PATIENTS: Fluent in English * PATIENTS: Age \>= 18 years * PATIENTS: Willing to provide contact information for eligible first-degree relatives * PATIENTS: \>= 2 first-degree relatives that are eligible for genetic testing and reside in the United States of America * FIRST-DEGREE RELATIVES: Proband is a COH patient and has consented to this study * FIRST-DEGREE RELATIVES: First-degree relative of proband * FIRST-DEGREE RELATIVES: Resides within the United States * FIRST-DEGREE RELATIVES: Has not undergone genetic testing for the known familial variant * FIRST-DEGREE RELATIVES: Are fluent in English * FIRST-DEGREE RELATIVES: Age \>= 18 years Exclusion Criteria: * PATIENTS: Unable to provide informed consent * PATIENTS: =\< 2 at-risk first-degree relatives who are eligible for genetic testing and/or reside within the United States * PATIENTS: Unwilling to provide contact information for family members * FIRST-DEGREE RELATIVES: Unable or unwilling to provide informed consent * FIRST-DEGREE RELATIVES: Have undergone genetic testing for the known familial variant * FIRST-DEGREE RELATIVES: Resides outside of the United States
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What it tests

  • Best Practice
  • Electronic Health Record Review
  • Personal Contact
  • Survey Administration
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Where

1 site
City of Hope Medical Center
Duarte, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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