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Vaping and Smoking Withdrawal Project

RecruitingNAAges 21 Years - 50 YearsAllState University of New York at Buffalo
NCT05772845 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The proposed research, which will systematically and comprehensively characterize the withdrawal among daily vapers compared to daily smokers of combustible cigarettes, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence/abuse liability and contributing to the development of therapies for tobacco/nicotine use, the leading preventable cause of death in the US.

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📋 Eligibility rules (as published)
Inclusion Criteria: * 6+ months of daily/near-daily nicotine vaping and/or cigarette smoking (to yield 160 vapers, 160 smokers, 50 dual users) * 200+ ng/mL cotinine on a commercially-available quick screen Current Exclusion Criteria: * intention to quit daily/near-daily vaping/smoking in the next month * current (2+ days out of the past 7) use of pipe tobacco, hookah/shisha, smokeless tobacco, dissolvable tobacco, nicotine pouches. For vaping group only, current (2+ days out of past 7) use of cigars, cigarillos, or filtered cigars that are filled with tobacco or a mix of tobacco and marijuana * current use of any smoking cessation medication * current severe substance dependence other than tobacco/nicotine (including cannabis; NIDA Modified ASSIST of 27+) * current (past 2 weeks) suicidal ideation with intent and/or plan * current antipsychotic medications or lifetime history of schizophrenia or bipolar disorder * pregnancy (intake urine screen) Original Exclusion Criteria that have been modified or eliminated: * \>1 use in past month of tobacco/nicotine products other than ENDS and combustible cigarettes (modified 5/19/25 - see current exclusion criteria) * alcohol: AUDIT \> 15 for males and \>13 for females (eliminated 7/25/23) * current major depression (PHQ-9\>11) (eliminated 7/25/23) * suicide risk (answer to question #9 on PHQ-9 is anything other than "Not at all") (modified 11/17/23 - see current exclusion criteria)
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What it tests

  • Acute (24-hour) abstinence
  • Ad libitum smoking/vaping
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Where

1 site
University at Buffalo
Buffalo, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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