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Glutamate Excitotoxicity and Its Role in Glioblastoma Biology

Recruitingn/aAges 18 Years - anyAllIRCCS San Raffaele
NCT05775458 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Gliomas are the most frequent type of primary brain tumors in adults; among them glioblastoma multiforme (GBM) is the most malignant, being associated with the worst prognosis. Glutamate (Glu) is an aminoacid, responsible for essential functions in the Central Nervous System (CNS), acting both as metabolite and neurotransmitter. It is essential for regulating cellular metabolism and developmental synaptogenesis, cellular migration, differentiation and death. Recent scientific evidences have demonstrated alteration in Glu synthesis and signaling being directly involved in GBM growth and invasion

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients with a brain lesion suspected for GBM, candidate to gross total tumor resection (GTR), followed by radiotherapy and chemotherapy (concomitant and adjuvant). * Patient able to provide informed consent. Exclusion Criteria: * Age \< 18 years * Liver disease * Severe anemia (Hb \<8mg/dl) * Pregnancy
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What it tests

  • Blood, CSF and tumor samples
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Where

1 site
IRCCS San Raffaele Scientific Institute
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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