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AV Junction Ablation or Optimal Medical Treatment in PatiEnts With Cardiac Resynchronization Therapy and Permanent Atrial Fibrillation

RecruitingNAAges 18 Years - 85 YearsAllUniversity Hospital Ostrava
NCT05776797 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A study comparing atrioventricular junction ablation (AVJA) versus continued optimum medical rate control in patients with cardiac resynchronization therapy (CRT) and atrial fibrillation (AF) with suboptimal heart rate control on optimum medication.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Treatment with CRT using either a biventricular pacemaker/defibrillator or conduction system pacemaker (\>6 months) * Diagnosis of AF and classified as: permanent AF or recurrent persistent AF, requiring emergency visits and/or hospitalizations (at least one in recent year) * Optimized HF medical treatment and rate control medication * BiVP% + ventricular premature complex (VPC%) \<99% and \>85% during the minimum period of 1 month while already on optimum medical therapy (applicable only for patients with permanent AF) * Age \>18 and \<85 years * Signed informed consent Exclusion Criteria: * myocardial infarction (MI) or coronary artery bypass graft (CABG) \<3 months * Technical failure of the CRT system * Intentional preference for spontaneous AV conduction * Expected survival \<1 year * Other significant comorbidities and/or conditions that interfere with the proper conduction of the trial * Dementia as assessed by mini-mental test (\<23 points)
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What it tests

  • Atrioventricular junction ablation in patients with cardiac resynchronization therapy (CRT)
  • Optimal medication treatment in patients with cardiac resynchronization therapy (CRT)
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Where

9 sites
Regional Hospital Liberec
Liberec, Czechia
University Hospital Ostrava
Ostrava, Czechia
Hospital Podlesí, Inc.
Třinec, Czechia
University Hospital Olomouc
Olomouc, Czechia
Hospital České Budějovice
České Budějovice, Czechia
St. Anne's University Hospital Brno
Brno, Czechia
University Hospital Brno
Brno, Czechia
Institute of Clinical and Experimental Medicine
Prague, Czechia

…and 1 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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