Low-dose Buprenorphine as a Modulator of Social Motivation in Schizophrenia

Inclusion Criteria: 1. Ages 18-60 2. able to understand spoken English sufficiently to comprehend testing procedures 3. score below the mean of participants screened previously screened on the Lubben Social Network Scale 4. DSM-5 diagnosis of schizophrenia 5. clinical stability (i.e., no inpatient hospitalizations for six months prior to enrollment, no changes in medication in for 6 months prior to enrollment, no current positive symptoms greater than moderate) c) no history of IQ less than 70 or developmental disability, based on medical history d) no current use of opioid medication e) no clinically significant neurological disease (e.g., epilepsy), cardiovascular condition (e.g. cardiac arrhythmia), or respiratory condition (e.g., asthma) based on medical history 1. no history of serious head injury (i.e., loss of consciousness longer than 1 hour, neuropsychological sequelae, cognitive rehabilitation treatment after head injury) based on medical history 2. no substance or alcohol use disorder in the past six months, or history of opioid use disorder 3. no sedatives, benzodiazepines within 24 hours of testing 4. no positive urine toxicology screen or visible intoxication on the day of assessment 5. no women who are pregnant or think that they might be pregnant, based on self-report and urine test