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Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm

RecruitingNAAges 18 Years - anyAllRadboud University Medical Center
NCT05779631 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A two-arm multicenter randomised controlled trial, comparing progression free survival, time to definitive treatment and cost-effectiveness of the standard of care (TURBT) and mpMRI followed by same-day cystoscopic bladder biopsy for diagnosis of patients with suspicion of muscle-invasive bladder cancer.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients (18+ years of age) * Clinically suspected MIBC * No lymph node or distant metastases * Written informed consent Exclusion Criteria: * Unable or unwilling to undergo mpMRI * Unfit for TURBT * Unfit for definitive treatment with curative intent * A history of cancer, including bladder cancer, except: non-melanoma skin cancer, prostate cancer on active surveillance or a solid malignant tumor ≥5 years disease-free since last treatment
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What it tests

  • mpMRI plus a same-day cystoscopic bladder biopsy
  • TURBT
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Where

19 sites
Jeroen Bosch ziekenhuis
's-Hertogenbosch, Netherlands
Ziekenhuisgroep Twente
Almelo, Netherlands
Meander MC
Amersfoort, Netherlands
Amsterdam UMC, location AMC
Amsterdam, Netherlands
Amsterdam UMC, location VUmc
Amsterdam, Netherlands
Antoni van Leeuwenhoek - Netherlands Cancer Institute
Amsterdam, Netherlands
OLVG
Amsterdam, Netherlands
Rijnstate ziekenhuis
Arnhem, Netherlands

…and 11 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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