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State of Hormones Impact Nociceptive Expression

Recruitingn/aAges 18 Years - 65 YearsAllUniversity of Alabama at Birmingham
NCT05787470 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The Investigators have recently published on differences in pain sensitivity measures between cis and trans individuals in the local area. The investigators observed the anticipated differences in pain sensitivity between CM and CW (CW \> CM), but found that the TW were phenotypically similar to CW in all measures. However, the investigators did not assess hormone level, nor did the investigators recruit TM participants. Here, with the assistance of two local community group stakeholders the investigators will recruit the following groups: CM, CW, TM+T (currently taking exogenous testosterone), TW+E (exogenous estradiol), TM, and TW (n=20/group). The investigators will use quantitative sensory testing to assess sensitivity to cold, pressure, and heat via standardized protocols. Blood samples will be taken for assessment of stress and reproductive hormone levels, immune cell populations a

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📋 Eligibility rules (as published)
Inclusion Criteria: * self-identification as one of the above gender identities * understanding of verbal and written English. * participants that have been on/off hormone treatment for at least 6 months Exclusion Criteria: * pain in at least 3/7 days/week for the past 3 months * HIV positive diagnosis * cardiovascular or pulmonary disease * regular use of opioid pain medications * uncontrolled hypertension (i.e. SBP/DBP of \> 150/95) * current illness accompanied by fever (body temperature \>38 °C) * prostatectomy, hysterectomy or oophorectomy * hospitalization due to psychiatric illness within the last 6 months.
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What it tests

  • Quantative sensory testing
  • Blood Draw
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Where

1 site
University of Alabama at Birmingham
Birmingham, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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