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Implementing ctDNA and Circular DNA in Patients With Localized Pancreatic Cancer

RecruitingNAAges any - anyAllCopenhagen University Hospital at Herlev
NCT05788744 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to investigate if plasma ctDNA and eccDNA before resection for suspicion of pancreatic ductal adenocarcinoma (PDAC) can predict early recurrence and overall survival, and to investigate if plasma ctDNA combined with CT scan and endoscopic ultrasound surveillance increases the median overall survival compared with standard-of-care surveillance.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Sub-study 1: Suspicion of PDAC tumor stage I-III, scheduled for pancreatic resection, with or without preoperative neoadjuvant chemotherapy. * Sub-study 2: . * PDAC tumor stage I-III * Has received intended curative resection (R0/R1) of PDAC * No signs of local recurrence or metastatic disease at a CT scan 4 months after the operation Exclusion Criteria: * Other cancers (excluding skin cancer other than melanoma) later than 3 years before inclusion * Patients who are unlikely to comply with the protocol, inability to return for subsequent visits) and/or otherwise considered by the Investigator to be unlikely to complete the study
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What it tests

  • ctDNA
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Where

5 sites
Aalborg Universitetshospital
Aalborg, Denmark
Aarhus Universitetshospital
Aarhus, Denmark
Copenhagen University Hospital - Rigshospitalet
Copenhagen, Denmark
Copenhagen University Hospital - Herlev and Gentofte
Herlev, Denmark
Odense Universitetshospital
Odense, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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