Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer

Inclusion Criteria: * Age ≥18 years * Histologically confirmed stage I, II, or III colon or rectal cancer * Completed surgical resection with curative intent * Completed other cancer-directed treatments * Engage in \<150 minutes per week of moderate- to vigorous-intensity structured endurance exercise * No planned major surgery during the study period * Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire * Ability to provide written informed consent * Provide written approval by a qualified healthcare professional * Willing to be randomized Exclusion Criteria: * Evidence of metastatic or recurrent colorectal cancer * Concurrently actively treated other (non-colorectal) cancer * Scheduled to receive other postoperative cancer-directed treatment(s) * Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks * Currently participating in another study with competing outcomes * Contraindications to magnetic resonance imaging * Any dietary condition or restriction that would limit tolerance of a mixed meal challenge * Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric, or other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol * Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol