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Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Universitaire, Amiens
NCT05791149 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Head and neck squamous cell carcinoma (HNSCC) are malignant tumors originating from the epithelial mucosa of the upper aerodigestive tract. The oral cavity is the most frequent location of HNSCC (oral squamous cell carcinoma: OSCC). Tobacco use and alcohol consumption are the greatest risk factors. The Hauts de France region has one of the highest incidence rates of OSCC. The overall survival of patients with OSCC remains low, with a 5-year overall survival rate of around 60%. In addition to the oncological prognosis, OSCCs and their treatment have a significant impact on the quality of life of patients. An early diagnosis of OSCC is recommended, but it remains difficult. It can be for example challenging to diagnose OSCC in a context of oral premalignant lesions. Identifying objective biomarkers of malignancy would be an advantage and would allow better progress in the field of precisio

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient group: * Patients from the maxillofacial surgery department treated for a histologically confirmed squamous cell carcinoma of the oral cavity * Patients whose first-line treatment decision at the multidisciplinary meeting in the service of Maxillofacial Surgery is surgery * Patients who have not yet been treated surgically or by neoadjuvant treatment * Patients over 18 years old * Patients who have provided free and informed consent in writing * Patients benefiting from a social security scheme Control group: * Patients in the maxillofacial surgery department not covered for head and neck cancer * Patients over 18 years old * Patients who have provided free and informed consent in writing * Patients benefiting from a social security scheme * Control group homogeneous with the patient group according to age, sex, tobacco and alcohol consumption Exclusion Criteria: * Patients with other types of cancer * Patients under the age of 18 * Pregnant or breastfeeding women * Patients under guardianship, curators, legal protection or deprived of liberty
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What it tests

  • saliva tube
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Where

1 site
Amiens University Hospital
Amiens, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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