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Pulmonary Immune Cell-microbiome Interactions in ARDS

Recruitingn/aAges 18 Years - anyAllHvidovre University Hospital
NCT05795257 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The overall aim is to compare the composition and spatial heterogeneity of the following in critically ill intensive care unit (ICU) patients: i) immune cell populations and their activation patterns, ii) the surrounding cytokine-chemokine milieu, including trans-compartmental fluxes of these mediators between the lung and bloodstream, and iii) the lung microbiome. Main hypotheses: * The immune cell population in bronchoalveolar lavage fluid (BALF) from patients with ARDS is dominated by neutrocytes, while T cells are depleted, and show evidence of hyper-activation and exhaustion * T cell hyper-activation and exhaustion is specifically compartmentalised to the lungs, and much more pronounced in moderate-to-severe than none-to-mild ARDS * Cyto- and chemokines derived from pulmonary immune cells are higher in moderate-to-severe than none-to-mild ARDS with a greater release from lungs to

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📋 Eligibility rules (as published)
Inclusion Criteria: * Inclusion criteria - moderate-to-severe ARDS * Admitted to the ICU at Hvidovre Hospital * Intubated within the past 72 hours * Moderate-to-severe ARDS according to the Berlin definition19 * Age ≥ 18 years Inclusion criteria - none-to-mild ARDS * Admitted to the ICU at Hvidovre Hospital * Intubated within the past 72 hours * None-to-mild ARDS according to the Berlin definition19 * Age ≥ 18 years Exclusion Criteria: * ARDS caused by COVID-19 * Absolute contraindications for bronchoscopy * Untreated malignant arrhythmia * Documented or suspected intracranial hypertension (intracranial pressure ≥ \> 15 mmHg) * One-lung ventilation * Severe coagulopathy
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What it tests

  • Bronchoalveolar lavage
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Where

1 site
Hvidovre Hospital, University of Copenhagen
Hvidovre, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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