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โ† Trials
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Measuring Oncological Value of Exercise and Statin

RecruitingPhase 3Ages 18 Years - 99 YearsAllTampere University Hospital
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In plain words

What the trial is, and whether it could suit you

The aim of the study is to find out whether supervised physical exercise during cancer drug treatment improves the effectiveness of the treatment in metastasized breast, kidney, ovarian and prostate cancer compared to unsupervised exercise. In addition, the investigators are investigating whether the use of atorvastatin combined with guided group exercise training would further improve the response to cancer treatment.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * The patient has metastatic prostate cancer, breast cancer, ovarian cancer or kidney cancer confirmed histologically and by imaging, for which 1st-line cancer drug treatment is started * Prostate cancer: First course of docetaxel treatment or second-generation antiandrogen treatment for metastatic prostate cancer. * Breast cancer: First-line medical treatment of metastatic breast cancer regardless of hormone receptor status. * Kidney cancer: Kidney cancer, for which 1st-line cancer drug treatment is started as tki monotherapy and/or IO monotherapy or as a combination therapy. * Ovarian cancer: stage III or IV cancer for which chemotherapy treatment is started. * The patient agrees to the study and signs a written informed consent. * Adult (18 years=\>) women (breast, ovarian and kidney cancer) and men (prostate and kidney cancer) are recruited for the study. * In women, the use of a reliable contraceptive during the intervention Exclusion Criteria: * High risk of bone fractures * Inability to physical exertion and/or unsuitability for cancer drug treatment * Poor co-operation ability for psychological reasons * Active use of cholesterol-lowering drugs * Severe liver or kidney failure * Troublesome side effects that occurred in the past during cholesterol medication * Continuous use of medicinal substances that interact with atorvastatin during the study period * A special group of subjects according to the EU Clinical Trials Regulation 536/2014 (e.g. pregnant or lactating women) Exclusion criteria in patients who are already using statin medication before the study: * High risk of bone fractures * Inability to physical exertion and/or unsuitability for cancer drug treatment * Poor co-operation ability for psychological reasons * Severe liver or kidney failure * A special group of subjects according to the EU Clinical Trials Regulation 536/2014 (e.g. pregnant or lactating women)
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What it tests

  • Guided physical exercise
  • Atorvastatin
  • Independent exercise
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Where

1 site
Tampere University Hospital
Tampere, Finland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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