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Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical Treatment

RecruitingNAAges 18 Years - 70 YearsAllGöteborg University
NCT05797558 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a prospective randomized controlled trial where quality of life and the effectiveness of treatment will be evaluated in 80 patients with confirmed unilateral primary aldosteronism ,randomly assigned to be either treated surgically with unilateral adrenalectomy or to receive medical treatment with eplerenone.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients with confirmed unilateral PA 2. Age 18-70 years 3. Candidate for surgical treatment 4. No contraindications for minimally invasive surgery or treatment with MRA 5. Understands oral and written information and provides oral and written informed consent. Exclusion Criteria: 1. Unwilling or unable to undergo surgery 2. Unwilling to accept medical treatment for 12 months and not receiving standard treatment (surgery) 3. Impaired renal function with eGFR \<45 ml/min/1,73m2 4. P-cortisol \>138 nmol/L following 1-mg overnight dexamethasone suppression test.
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What it tests

  • Unilateral adrenalectomy
  • Medical treatment (eplerenone)
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Where

3 sites
University of Gothenburg
Gothenburg, Sweden
Karolinska University Hospital, Stockholm, Sweden.
Stockholm, Sweden
Umeå University, Umeå, Sweden.
Umeå, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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