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The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty

RecruitingNAAges 41 Years - 80 YearsAllLondon Health Sciences Centre Research Institute …
NCT05800457 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Osteoarthritis (OA) is the most common joint disease, causing severe pain due to joint inflammation (synovitis). While total knee arthroplasty (TKA) is commonly performed to reduce pain, 20% of patients are dissatisfied with their outcome post-surgery. This dissatisfaction is caused by persistent pain post-TKA due to synovitis that is not routinely removed during surgery. To address this problem, a synovectomy can be performed during TKA, which involves resecting the inflamed layer of tissue lining the joint, called the synovium, and its associated sensory nerve endings. Since the synovium will regenerate in the months post-surgery, synovectomy only transiently reduces pain after TKA. The proposed study will help ascertain the benefits and effects of synovectomy in patients who are more likely to experience poor satisfaction (driven mostly by pain) post-TKA. This study will include 62 pa

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Males or females over the age of 40 diagnosed with knee osteoarthritis 2. Scheduled for first unilateral total knee arthroplasty 3. Moderate to severe (at least grade two) synovitis and synovial hyperplasia, as determined by ultrasound assessment 4. Referred to the Pre-Admission Clinic at University Hospital Exclusion Criteria: 1. Bilateral, uni-compartmental, or revision total knee arthroplasty 2. Osteoarthritis due to genetic syndromes (e.g., Ehlers-Danlos Syndrome, etc.) 3. Known inflammatory arthropathy, another rheumatic disease, or disease-modifying anti-rheumatic drug (DMARD) use (e.g. methotrexate, hydroxychloroquine, sulfasalazine, leflunomide, TNF inhibitors, etc.) - note: Gout is NOT an exclusion 4. Joint injection (steroid or viscosupplement) within 12 weeks of Pre-Admission Clinic appointment date 5. Cannot read, write, or understand English (printed instructions are provided in English only) 6. Any factors precluding patients from attending follow-up appointments (e.g., socio-economic limitations, distance from clinic, no access to home/cell phone, etc.). 7. Cognitive impairment or psychological problems that preclude the ability to understand instructions 8. Not able to follow up at routine standard of care post-operative visits
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What it tests

  • Partial synovectomy
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Where

1 site
London Health Sciences Centre - University Hospital
London, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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