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Cerebral Perfusion Variation During Blood Pressure Changes in ICU

Recruitingn/aAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT05804773 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The risk associated with arterial hypotension during anesthesia for intensive care sedation has been demonstrated, but the threshold at which consequences for perfusion of one or more organs appear varies according to the mechanism of hypotension, associated abnormalities (HR, cardiac output and oxygen transport) and the patient's terrain. Currently, a mean arterial pressure greater than 60 mm Hg (1) and a reduction of less than 30-50% from the value measured before sedation are commonly used to ensure good perfusion of all organs. In intensive care, it is recommended to maintain a MAP between 60 and 70 mmHg and a Cerebral Perfusion Pressure (CPP) \> 50 mmHg for neurocompromised patients with Intra Cranial pressure (ICP) measure. Normally, cerebral blood flow is self-regulated, allowing adaptation of cerebral blood flow to oxygen requirements at different levels of high and low blood pr

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients (\> 18 years old) * Requiring an intensive care unit admission * Informed patient who has expressed his/her non-opposition to participating in this research or, if applicable, trusted person/relative of patient unable to express his/her wishes Exclusion Criteria: * Patients under 18 years of age. * Patient, or if applicable, trusted person / close relative / parent of patient unable to express his/her will, opposed to participation in the protocol * Pregnant woman * Patient under judicial protection * Patient not affiliated to a social health system
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What it tests

  • Non-invasive Measurement of cerebral blood velocity in the middle cerebral artery by transcranial pulsed Doppler (TCD) (Mean velocity, Vm, cm/s)
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Where

1 site
Hôpital Lariboisière
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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