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The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis

RecruitingPhase 4Ages 50 Years - anyAllCentre hospitalier de l'Université de Montréal (C…
NCT05806021 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Osteoarthritis of the knee is a common problem that is increasing in prevalence as the population ages. In a knee with osteoarthritis, there is variable damage to the articular cartilage and underlying bone that can cause varying degrees of pain. When pain is bothersome, osteoarthritis is treated to improve functional abilities. One of the most recognized and used treatments is intra-articular cortisone injection. Cortisone is a powerful anti-inflammatory drug that is used to reduce pain. Unfortunately, cortisone can have significant side effects, even when injected locally. The frequency and intensity of these side effects depend largely on the total dose injected. The main side effects include increased blood sugar levels, increased blood pressure and a temporary decrease in the secretion of the stress hormone, cortisol. In the long term, a decrease in articular cartilage thickness i

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📋 Eligibility rules (as published)
Inclusion Criteria: * Symptomatic primary gonarthrosis of over 6 months duration (gonarthrosis according to the American College of Rheumatology criteria) * Grade 1 to 3 Kellgren-Lawrence femorotibial osteoarthritis * Knee pain provoked by activity over 4 and under 8 on 10 (Visual Analog Scale) Exclusion Criteria: * Bilateral symptomatic primary gonarthrosis * Grade 4 Kellgren-Lawrence femorotibial osteoarthritis * Isolated patellofemoral osteoarthritis * Intra-articular corticosteroid infiltration to the knee within the past 3 months or chronic use of per os corticosteroid * Intra-articular hyaluronic acid infiltration within the past 12 months. * Intra-articular infiltration of platelet-rich plasma within the past 12 months. * Disease affecting the study joint (systemic inflammatory disease, history of septic arthritis, osteonecrosis, etc.). * Suspicion or presence of active local infectious process. * Presence or suspicion of local neoplasia or metastasis * Recent severe trauma to the knee (≤ 3 months) * Significant cognitive impairment or inadequate language proficiency not allowing adequate response to study questionnaires * Any other serious medical condition that does not allow participation in the study or may be a contraindication to cortisone injection
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What it tests

  • Triamcinolone Acetonide
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Where

1 site
Centre Hospitalier Universitaire de Montréal - Hôtel-Dieu
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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