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Medically Assisted Fertilization Techniques in Systemic Immunoreumatologic Diseases

Recruitingn/aAges 18 Years - 50 YearsFemaleIRCCS San Raffaele
NCT05807256 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Systemic rheumatological diseases often occur in young women of childbearing age and can therefore impact fertility. There are diseases, such as arthritis, which present no contraindication to assisted reproductive techniques (ARTs), because there is no influence on the disease itself if the disease activity at conception is stable. On the other hand, patients suffering from connective tissue diseases, primarily Systemic Lupus Erythematosus (SLE) and patients suffering from primary or SLE-related Anti-Phospholipid Antibody Syndrome (APS), deserve more targeted therapies both in the context of ARTs and in the ensuing pregnancy. To evaluate the response to ARTs in patients with systemic rheumatological diseases, both in terms of reactivation of the underlying pathology and in terms of ARTs outcome.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients diagnosed with systemic immunoreumatologic disease such as SLE, APS, RA, SpA, SclS, SS, PM-DM, vasculitis * patients who have performed one or more PMAs between January 2000 and April 2021 * patients who had their last follow-up by February 2022 Exclusion Criteria: * Patients diagnosed with only one organ autoimmunity (e.g., diabetes mellitus I, thyroiditis of Hashimoto's, celiac disease or chronic inflammatory bowel disease in the absence of systemic disease associated); * patients with severe renal failure, significant pulmonary hypertension or cardiomyopathy severe.
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What it tests

  • collection and analysis of treatments and procedures already performed by normal clinical practice
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Where

1 site
San Raffaele Hospital
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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