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Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals

RecruitingPhase 2Ages 65 Years - 85 YearsAllMedical College of Wisconsin
NCT05808686 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of exercise. Participants will come in for 3 study visits and get home-based ischemic conditioning. At Study Visit 1, participants will be assessed for their frailty and physical function. Afterwards, they will perform an exercise test. At Study Visit 2, patients will undergo 2 microvascular assessments, perform a high-intensity exercise, then undergo the same 2 microvascular assessments again. Participants will be given a handheld sphygmomanometer and a blood pressure cuff to take home. Depending on which group the participants get randomized into, participants will place the blood pressure cuff around their non-dominant upper arm and inflate to either a low or hig

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women and men ages 65-85 years of age Exclusion Criteria: * Myocardial infarction in last 6 months * morbid obesity (BMI \>40) * heart failure * uncontrolled hypertension * other condition that precludes high intensity exercise (ex, neurological disorder, acute systemic infection) * history of blood clots in the extremities * any condition in which compression of the arm or transient ischemia is contraindicated (e.g., wounds in the arm).
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What it tests

  • Ischemic Conditioning
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Where

1 site
Froedtert Hospital
Wauwatosa, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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