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Ultrasonography in Children With First Febrile Urinary Tract Infection

Recruitingn/aAges 2 Months - 3 YearsAllIRCCS Burlo Garofolo
NCT05814250 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In recent decades, different tests have been recommended by guidelines in the management of first febrile urinary tract infection (fUTI) in children, including kidney ultrasound (KUS), cystography (VCUG) and renal scintigraphy in order to exclude underlying kidney anomalies. The majority of guidelines, continue to recommend a routine KUS for all children at the first fUTI. On the other hand, as this approach is not based on robust evidence, other guidelines suggest that KUS should only be performed on selected patients according to specific risks. Despite being a non-invasive and radiation-free method, KUS tests negative in 83% of cases of fUTIs and possesses low specificity for low grade vesico-ureteral reflux (VUR). Since VUR is the most commonly associated renal malformation with UTI, it is evident that all the guidelines focus on the research of VUR, especially in times when antenata

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📋 Eligibility rules (as published)
Inclusion Criteria: \- Patient with first episode of fUTI that subsequently do KUS. Exclusion Criteria: * patients with previous episodes of UTIs * patients on antibiotic prophylaxis * previous finding of malformative uropathies or cystic disease * prenatal diagnosis of CAKUT with the following parameters: Presence of oligohydramnios, alterations in renal number, location and echo structure, bladder alteration, dilations of the renal pelvis and ureters
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What it tests

  • Not listed
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Where

3 sites
AOU Meyer IRCCS
Florence, Italy
IRCCS Policlinico Cà Granda
Milan, Italy
IRCCS materno infantile Burlo Garofolo
Trieste, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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