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Culturally Adapted Psychosocial Interventions for Early Psychosis in a Low-resource Setting

RecruitingNAAges 18 Years - anyAllPakistan Institute of Living and Learning
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In plain words

What the trial is, and whether it could suit you

Primary Aims: To determine the clinical efficacy of Culturally adapted Cognitive Behavioral Therapy (CaCBT) and Culturally adapted Family Intervention (CulFI) compared to Treatment As Usual (TAU) on reducing overall symptoms of psychosis in patients with First Episode Psychosis (FEP) in Pakistan. Secondary Aims: 1. To determine the efficacy of CaCBT and CulFI compared to TAU on positive and negative symptoms of psychosis, general psychopathology, depressive symptoms, quality of life, general functioning, and insight in patients with FEP in Pakistan. 2. To determine the efficacy of CaCBT and CulFI compared to TAU on improving carer experience, carer wellbeing, carer illness attitudes and symptoms of depression and anxiety in family and carers of patients with FEP in Pakistan. 3. To determine the comparative effect of CaCBT and CulFI in improving patient and carer related outcomes in in

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria for patient participants: * Individuals of all genders aged over 18 years; diagnosis of schizophrenia confirmed by Structured Clinical Interview for DSM (SCID) meeting DSM-5 criteria for schizophrenia, schizophreniform or schizoaffective psychosis * Scored at least 4 on the PANSS delusions or hallucinations items, or at least 5 on suspiciousness, persecution, or grandiosity items * stable on medication for the past four weeks * in contact with mental health services * within 3 years of diagnosis * able to demonstrate the capacity to provide informed consent to take part in the study * potential participants must have a carer or relative who is also willing to participate in the study to be eligible Exclusion Criteria for patient participants: * Active DSM-5 substance use disorder (except nicotine or caffeine) or dependence within the last three months * A score of 5 or more on the PANSS conceptual disorganisation item * Individuals who have received structured psychological intervention within the past 3 months * Relevant CNS or other medical disorders that would impact participation * Diagnosis of intellectual disability * Unstable residential arrangements Family member/Carer participant inclusion criteria: * Living with or spending at least 10 hours per week in face-to-face contact with an individual with early psychosis and assuming a caring role * Age\>18 years * Able to give informed written consent. Family member/Carer participant exclusion criteria: * Active DSM-5 substance use disorder * Received psychological intervention within the past 3 months * Unstable residential arrangements.
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What it tests

  • CaCBT for psychosis
  • Culturally adapted Family Intervention (CulFI) for psychosis
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Where

1 site
Civil hospital
Karachi, Pakistan
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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