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Multilayer Biological Characterization of Advanced Follicular Lymphoma: a Translational Study From FIL_FOLL12 Trial

Recruitingn/aAges 18 Years - anyAllFondazione Italiana Linfomi - ETS
NCT05816850 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a Multicenter, Retrospective, Biological study ancillary to FOLL12 trial to evaluate the role of EZH2 aberrations in patient with FL treated with immunochemotherapy. Moreover, several novel biomarkers of FL will be investigated.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient enrolled in the FIL\_FOLL12 trial (documented by the signature of the study informed consent); * Availability of biological samples: bone marrow aspirate, peripheral blood and/or FFPE diagnostic sample (nodal or extranodal); Exclusion Criteria: * None
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What it tests

  • EZH2 mutations/CNAs by droplet digital PCR (ddPCR)
  • EZH2-derived gene expression signature by RNA-Seq
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Where

26 sites
A.O. SS. Antonio e Biagio e Cesare Arrigo, S.C. Ematologia
Alessandria, Italy
Nuovo Ospedale degli Infermi, SSD Ematologia
Biella, Italy
ASST Spedali Civili di Brescia - Ematologia
Brescia, Italy
Azienda Ospedaliera Universitaria Policlinico - S. Marco, UOC di Ematologia
Catania, Italy
A.O. S. Croce e Carle, S.C. di Ematologia e Trapianto di Midollo Osseo
Cuneo, Italy
Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia
Florence, Italy
Ospedale Policlinico San Martino S.S.R.L. - IRCCS per l'Oncologia, Ematologia e terapie cellulari
Genova, Italy
IRCCS Istituto Romagnolo per lo studio dei Tumori "Dino Amadori" - IRST S.R.L., Ematologia
Meldola, Italy

…and 18 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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