Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal Failure

Inclusion Criteria: 1. Acute kidney injury treated by continuous renal replacement therapy in ICU less than 7 days, 2. At least 1 organ failure during ICU in addition to AKI (mechanical ventilation or oxygen therapy or vascular filling \> 1000ml or vasopressor exposure \> 12 hours), 3. Weight loss of less than 3% since starting a net UF or Cumulative UF net less than 2000ml before inclusion, 4. Norepinephrine \< 0,5 µg/kg/min, 5. Absence of hypoperfusion signs defined by the presence of at least 2 out of 4 criteria: * TRC \> 3s at the finger * Marbrure score \> 2 * Lactate \> 2 mmol/L * ScVO2\< 60%, 6. Fluid overload defined as follows : * fluid overload \> 5% of base weight (based on cumulative fluid balance or a weight gain) and/or * Obvious oedema of the lumbar region or flanks (oedema \> 1cm bucket depth). Exclusion Criteria: 1. Chronic renal failure hemodialyzed before admission to the ICU, 2. Mechanical circulatory support (ECMO, LVAD), 3. Pregnant, child -bearing age or lactating women, 4. Stroke based on the combination of central neurological symptoms (aphasia, hemiplegia, hemiparesis) associated with compatible brain imaging, less than 30 days, 5. Intestinal ischemia less than 7 days documented non-operated, 6. Interventional study participation or exclusion period on going,that may interfere with the present study 7. Guardianship, curatorship or safeguard of justice, 8. Absence of signature of free and informed consent by the patient and/or relative, 9. Patients not affiliated to a social security scheme or beneficiaries of a similar scheme