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Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy Adults

RecruitingNAAges 18 Years - 65 YearsAllUniversity Hospital, Basel, Switzerland
NCT05819476 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is to investigate the effect of open-label placebo (OLP) application on acute pain in an experimental model of acute pain (simulating wound pain: this installation will apply monophasic, rectangular electrical pulses of 0.5ms duration with alternating polarity at 2 Hz frequency. The current will be increased to target a pain rating of 6 of 10 on the NRS (0 = no pain, 10 = worst imaginable pain). Three further adjustments in current will be made every 5 minutes for the next 15 minutes to compensate for habituation. This final current will be kept constant until the end of the particular experiment). In Part 1 duration of OLP analgesia will be examined, and onset and size of the effect will be reevaluated. In Part 2 of this study outcomes between subjects receiving one OLP injection, subjects receiving one repetition of the injection on a fixed time point and subjects receivin

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy volunteers (ASA Class I or II), aged 18 to 65 years * BMI between 18 and 25kg/m2 * Able to understand the study and the NRS * Able to give informed consent Exclusion Criteria: * Participation in a previous open-label placebo study; for Part 2, this includes Part 1 of this study * Regular intake of medications or drugs potentially interfering with pain sensation (analgesics, opioids, antihistamines, calcium and potassium channel blockers, serotonin/ noradrenaline reuptake inhibitors, corticosteroids) * Neuropathy * Chronic pain * Neuromuscular disease * Dermatological disease (i.e. Atopic Dermatitis) * Psychiatric disease * Pregnancy / Lactation
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What it tests

  • OLP-injection
  • Scripted Evidence-based treatment rationale
  • Experimental model of acute pain
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Where

1 site
University Hospital of Basel (USB); Department of Anaesthesiology
Basel, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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