Coronary CT-Derived FFR-Guided Strategy Versus Medical Therapy

Inclusion Criteria: * Age ≥ 18 years, with at least one vessel has CT-derived FFR≤0.80 * Patients with chronic coronary syndromes * Signed written informed consent Exclusion Criteria: * The patient has a known hypersensitivity or contraindication to any of the following medications: Heparin, Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Contrast media (Patients with documented sensitivity to contrast media which can be effectively pre-medicated with steroids and diphenhydramine \[e.g. rash\] may be enrolled) * Prior percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) * Sinus arrhythmia, cardiogenic shock, or severe heart failure (NYHA≥III) * Inability or unwillingness to undergo CT scan or coronary angiography * Patients on hemodialysis or with severe hepatic or renal insufficiency * Left main coronary artery stenosis ≥ 50% * Target vessel total occlusion * Pregnancy or intention to become pregnant during the course of the trial * Patients with a life expectancy less than 2 years