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Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients

RecruitingPhase 4Ages 18 Years - anyAllDr. Stephanie Sibley
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In plain words

What the trial is, and whether it could suit you

A double-blind, multi-centre, randomized, placebo-controlled, feasibility pilot trial in the prevention of new onset atrial fibrillation of critically ill patients admitted to an ICU.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria 1. Age โ‰ฅ18 years; 2. Admitted to an ICU with one or more of the following: 1. Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (\>10L/min) or invasive mechanical ventilation with an expected duration \>24 hours for respiratory failure (hypercarbic or hypoxic) 2. Vasopressor or inotropic support with an expected duration of \>24 hours 3. Cardiac arrest 3. Continuous cardiac monitoring. Exclusion Criteria 1. Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for \>18 hours 2. Receiving IMV for airway protection only (for example, isolated head trauma) 3. Active atrial fibrillation at the time of enrolment 4. On oral or continuous infusion of Amiodarone 5. Unlikely to survive \>24 hours or palliative patients 6. Cardiac surgery patients 7. Patients requiring parenteral magnesium therapy (e.g. pre-eclampsia, asthma) 8. Patients receiving dialysis 9. Positive pregnancy test (females \<50 years old) 10. Previously enrolled in this trial 11. Treating physician refuses enrollment
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What it tests

  • Magnesium sulfate
  • Placebo
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Where

4 sites
St Joseph's Healthcare Hamilton
Hamilton, Canada
Kingston Health Sciences Centre
Kingston, Canada
The Ottawa Hospital - General Campus
Ottawa, Canada
The Ottawa Hospital - Civic Campus
Ottawa, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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