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Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

RecruitingNAAges 65 Years - anyAllUniversity of Florida
NCT05830942 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 65+ * Objective executive function decline, based on standardized cognitive assessments. * Subjective cognitive decline, based on the question: "During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?" * Ability to walking independently for 6 minutes (use of cane permitted) Exclusion Criteria: * Major cognitive disorder that interferes with independence * Percentile score less than 10th percentile on standardized cognitive assessments * Medications that are thought to influence tDCS neuroplasticity. * Contraindications to tDCS or MRI.
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What it tests

  • Walking Exercise
  • Prefrontal Active tDCS
  • Prefrontal Sham tDCS
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Where

2 sites
University of Florida
Gainesville, United States
Brooks Rehabilitation
Jacksonville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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