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Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

RecruitingNAAges 18 Years - 80 YearsAllStanford University
NCT05833217 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC). This study looks at whether adipose (fat) tissue contributes to PASC by driving chronic inflammation or by serving as a reservoir for SARS-CoV-2 persistence. The results will not only determine whether obesity and IR are risk factors for PASC, but will also define fundamental biology that sets the stage for the investigation of novel or existing therapies that target the causal pathways identified.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Ages 18 to 80 * BMI ≥ 25 kg/m2 * not currently pregnant Exclusion Criteria: Arm 2 (Adipose Tissue Biopsy) exclusions include * pregnancy * prior liposuction * recent change in weight (\> 2 kg in one month) * bleeding disorders * anticoagulant use Arm 3 (healthy controls only) exclusions include patients with * major organ disease * diabetes * history of liposuction * bariatric surgery * eating disorders * psychiatric disorders * pregnancy or lactation * recent change in weight (over the past 12 weeks), * use of weight loss medication or oral steroids * hematocrit \< 33% * fasting glucose \>= 126 mg/dL * blood pressure \>160/100 mmHg
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What it tests

  • Adipose Tissue Biopsy
  • Steady State Plasma Glucose (SSPG) Test
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Where

2 sites
Clinical and Translational Research Unit
Palo Alto, United States
Stanford Health
Palo Alto, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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