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Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery

Recruitingn/aAges 18 Years - anyAllUniversität Münster
NCT05833828 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. adult patients undergoing on- or off-pump coronary artery bypass graft surgery 2. written informed consent Exclusion Criteria: 1. emergency surgery in the context of acute coronary syndrome 2. ACE-inhibitor or Angiotensin 1 (AT1)-receptor-blocker intake that was not paused on the day of surgery 3. Chronic kidney disease with estimated glomerular filtration rate (eGFR)\<30ml/min/1.73m² 4. Severe structural lung disease (asbestosis, silicosis, severe sarcoidosis, tuberculosis, severe emphysema, chronic obstructive pulmonary disease (COPD) Gold 3-4, lung fibrosis) 5. Chronic pulmonary hypertension 6. Pregnancy or breastfeeding 7. Persons with any kind of dependency on the investigator or employed by the institution responsible or investigator 8. Persons held in an institution by legal or official order
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What it tests

  • on-pump surgery
  • off-pump surgery
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Where

2 sites
Deutsches Herzzentrum der Charité
Berlin, Germany
University Hospital Münster; Department of Anesthesiology, Intensive Care Medicine and Pain Medicine
Münster, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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