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Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

RecruitingPhase 1, Phase 2Ages 18 Years - 75 YearsAllTenaya Therapeutics
NCT05836259 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a first-in-human, non-randomized, open-label study designed to evaluate the safety, tolerability, and pharmacodynamics (PD) of TN-201 in adult patients with symptomatic hypertrophic cardiomyopathy (HCM) caused by mutations in the MYBPC3 gene.

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📋 Eligibility rules (as published)
Inclusion Criteria: * MYBPC3 mutation * Hypertrophic Cardiomyopathy (obstructive and nonobstructive) * Left Ventricular Ejection Fraction ≥45% * NYHA Functional Class II or III symptoms * NT-proBNP ≥160pg/ml Exclusion Criteria: * High AAV9 neutralizing antibody titer
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What it tests

  • TN-201
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Where

10 sites
UC San Diego Altman Clinical and Translational Research Institute - Center for Clinical Research
La Jolla, United States
University of California San Francisco
San Francisco, United States
Emory University
Atlanta, United States
Brigham and Women's Hospital
Boston, United States
Mayo Clinic
Rochester, United States
The Christ Hospital Physicians - The Ohio Heart and Vascular Center
Cincinnati, United States
Cleveland Clinic
Cleveland, United States
Oregon Health & Science University
Portland, United States

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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