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Estetrol/Drospirenone to Reduce the Average Size of Endometriomas

RecruitingPhase 4Ages 18 Years - anyFemaleAndrew Zakhari
NCT05837624 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Endometriosis, a chronic gynecological disorder associated with pain and infertility, is a common condition affecting approximately one in ten women. Up to 50% of patients with endometriosis have ovarian endometriomas (or "chocolate cysts"). These cysts directly impact fertility and ovarian reserve (ie. ability to have children) and can cause additional symptoms in women such as added pain, discomfort, and surgical emergencies (cyst rupture, or more rarely twisting). While endometriomas tend to require surgical excision as a solution, medical management with a variety of medications has been shown to be effective in reducing their size. Medical management (ie. medications and treatments that don't involve surgery) to reduce cyst size can help relieve symptoms either as a long term solution, before fertility treatments, or temporarily until surgery can be offered. Because the COVID-19 pa

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📋 Eligibility rules (as published)
Inclusion Criteria: * Equal to or greater than 18 years old * Has at least one ovarian endometrioma, of at least 3 cm * Seeking a hormonal treatment for their endometrioma(s) Exclusion criteria: * Any allergy or contraindication to the study drug * Inability to provide informed consent * Any hormone use, from the following list, within last 3 months (excluding hormones used for ovarian stimulation for fertility treatments): Estrogen (agonist or antagonist), Progestogen (agonist or antagonist), Androgen (agonist or antagonist), GnRH (agonist or antagonist), Cabergoline
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What it tests

  • Estetrol/Drospirenone
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Where

1 site
McGill University Health Center
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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