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Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients

Recruitingn/aAges any - 9 YearsAllWake Forest University Health Sciences
NCT05837936 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Because Propofol is the primary "anesthetic agent," and inhalational agents remain in trace quantities at the end of the procedure Sevoflurane initiated intravenous anesthesia (SIIVA) or not present at all Total intravenous anesthesia (TIVA) it is likely that different criteria may be predictive of extubation success in these patients compared to inhalational anesthesia.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Pediatric patients \<10 years of age * Undergoing elective or emergency surgery with planned airway instrumentation with an endotracheal tube (ETT) * Patients having general anesthesia with a planned SIIVA or TIVA technique * Patients with an end tidal agent concentration of Sevoflurane\<0.1% at the time of emergence and extubation * following sevoflurane induction to place IV Exclusion Criteria: * History of home oxygen use or ventilator dependence * Patients with cyanotic congenital heart disease * Patients undergoing anesthesia for imaging procedures alone * Patients intended to be managed with supraglottic airway * Patients having an anesthesia time \< 30 minutes * Monitored Anesthesia Care (not general anesthesia) * Patients with contraindication to receiving Propofol (i.e. mitochondrial myopathy)
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What it tests

  • Total intravenous anesthesia (TIVA)
  • Sevoflurane initiated intravenous anesthesia (SIIVA)
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Where

2 sites
Atrium Health Wake Forest Baptist
Winston-Salem, United States
Perth Children's Hospital
Perth, Australia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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